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HomeminewsStem Cells Return Sight to Wet AMD Patients

Stem Cells Return Sight to Wet AMD Patients

Patients with wet age-related macular degeneration (AMD), who received a new treatment derived from stem cells, have regained reading vision.

The study is a major milestone for the London Project to Cure Blindness, a partnership between Moorfields Eye Hospital NHS Foundation Trust, the UCL Institute of Ophthalmology and the National Institute for Health Research. Professor Pete Coffey from UCL said the research may lead to “an affordable ‘off-the-shelf’ therapy… within the next five years”. However, Macular Disease Foundation Australia has cautioned, more work is needed before this can occur.

Published in Nature Biotech, the study described the implantation of a specially engineered patch of retinal pigment epithelium cells derived from embryonic stem cells to treat people with sudden severe sight loss from wet AMD. It may also help treat dry AMD in the future. This is the first description of a complete engineered tissue successfully used in this way.

Two patients underwent the procedure; a woman in her early 60s and a man in his 80s with severe wet AMD and declining vision.

The patients… went from not being able to read at all, even with glasses, to reading 60-80 words per minute with normal reading glasses

The study investigated whether the diseased cells at the back of the patients’ affected eyes could be replenished using the stem cell based patch. A specially engineered surgical tool was used to insert the patch under the retina in the affected eye of each patient in an operation lasting one to two hours.

The patients were monitored for 12 months and reported improvements to their vision.

They went from not being able to read at all, even with glasses, to reading 60-80 words per minute with normal reading glasses.

Speaking of the potential for this procedure, Dee Hopkins CEO of Macular Disease Foundation Australia said, “While the initial results from this study are very exciting, especially regarding the improvement in vision, we can’t draw too many conclusions from two patients over only 12 months. A vast amount of additional research is needed to confirm safety, long term efficacy and also to determine the most appropriate time to provide the treatment. Perhaps more important is to determine whether this type of treatment could be of benefit for people with late dry AMD (geographic atrophy) where there is currently no treatment available.”