Real-world data from the Save Sight Keratoconus Registry has found similar outcomes in a comparison of transepithelial and epithelium-off crosslinking.
The findings have been published in the American Journal of Ophthalmology International.1
Corneal cross-linking is a standard procedure for the treatment of progressive keratoconus. There have been several variations made to the crosslinking procedure to try to optimise the technique, including the use of supplemental oxygen, pulsed ultra-violet light (UV) exposure, and leaving the epithelium intact.
the study highlights the value of using the registry – which is available to clinicians free of charge – to monitor treatment outcomes in patients with keratoconus
Transepithelial crosslinking allows for the protective epithelial barrier to remain completely intact with riboflavin application and UV light. It aims to reduce the risks of microbial keratitis, discomfort, and complications like corneal haze, oedema, and thinning.
Based on the Save Sight Keratoconus Registry data, the study authors have demonstrated that when compared to epithelium-off crosslinking, transepithelial crosslinking was similarly effective as measured by visual acuity and corneal curvature (keratometry) over a 12-month period.
The study authors hope the findings will help guide clinicians’ when informing their patients of crosslinking options and deciding between epithelium-off and transepithelial crosslinking in clinical practice.
“Registry data, such as the Save Sight Keratoconus Registry, holds such great potential in guiding and improving real-world clinical practice to work towards better patient outcomes,” said first author Dr Grace Borchert.
Dr Himal Kandel, Kornhauser Research Fellow at the Sydney Medical School, The University of Sydney said the study highlights the value of using the registry – which is available to clinicians free of charge – to monitor treatment outcomes in patients with keratoconus.
Senior author, Professor Stephanie Watson OAM said the findings “emphasise the importance of real-world evidence in advancing our understanding of keratoconus treatment options”.
“With data from the Save Sight Keratoconus Registry, clinicians can make more informed decisions for their patients, balancing safety and efficacy. This registry continues to be an invaluable resource, helping us refine and improve patient care.”
Reference
1. Borchert GA, Kandel H, Watson SL, et al. Save Sight Keratoconus Registry Study: Transepithelial versus epithelium-off corneal crosslinking. AJO International 2024;1(4): 100073. doi: 10.1016/j.ajoint.2024.100073.
