Novatears by AFT Pharmaceuticals is a preservative-free, phosphate-free, water-free, osmolarity-free, and steroid-free formulation of 100% perfluorohexyloctane to treat the symptoms of dry eye disease (DED).
Perfluorohexyloctane has a unique molecular structure that effectively inhibits tear film evaporation,1-3 likely by acting as a functional substitute for the tear film lipid layer. Given that lipid layer deficiency and associated evaporative dry eye are key contributors in the majority of DED cases,4-6 Novatears offers a targeted approach to the number one cause of DED.
Across three Phase 3 trials,7-9 Novatears produced meaningful, consistent reductions in both signs and symptoms of DED as early as week one, with sustained efficacy through 52 weeks. Statistically significant and clinically meaningful reductions in the severity and frequency of DED symptoms were observed as early as the third day of treatment.
In a Phase 4 trial,10 Novatears provided immediate symptom relief after a single instillation, with significant reductions in symptom severity and frequency over two weeks.
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